A successful pregnancy requires a fine-tuned and highly regulated balance between
immune activation and embryonic antigen tolerance. Since the fetus is semi-allogeneic, the …

The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …

Organismal function is, to a great extent, determined by interactions among their
fundamental building blocks, the cells. In this work, we studied the cell-cell interactome of …

This article summarizes the molecular and cellular mechanisms that regulate the activity of
indoleamine 2, 3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic …

Differentiation of endometrial stromal cells and formation of new maternal blood vessels at
the time of embryo implantation are critical for the establishment and maintenance of …

The objective was to examine if IVF/ICSI repeated implantation failures (IF) or recurrent
miscarriages (RM) could be related to preconceptional endometrial deregulations. IF was …

The role of progesterone in modulating dendritic cell (DC) function following stimulation of
different TLRs is relatively unknown. We compared the ability of progesterone to modulate …

One pivotal aspect of early pregnancy is decidualization. The decidualization process
includes two components: the differentiation of endometrial stromal cells to decidual stromal …

Pregnancy is a complex but well-arranged process, and a healthy fetus requires immune
privilege and surveillance in the presence of paternally derived antigens. Maternal and fetal …

Understanding the evolutionary adaptation of the immune system to the developing fetus
and placenta represents one of the most fascinating problems in reproductive biology …