Contact lenses represent a widely utilized form of vision correction with more than 140
million wearers worldwide. Although generally well-tolerated, contact lenses can cause …

Mutations in the death receptor FAS, or its ligand FASL cause autoimmune
lymphoproliferative syndrome, whereas mutations in caspase-8 or its adaptor FADD—which …

Cytokines and extracellular vesicles are two methods of initiating and maintaining cellular
crosstalk. The role of cytokines in the initiation, progression, and resolution of inflammation …

Neutrophils are implicated in the pathogenesis of tuberculosis (TB), a disease caused by
Mycobacterium tuberculosis infection, but the mechanisms by which they promote disease …

The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the
cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ …

In an inflammatory setting, macrophages can be polarized to an inflammatory M1 phenotype
or to an anti-inflammatory M2 phenotype, as well as existing on a spectrum between these …

Neutrophils are the first responders to sites of inflammation when the intestinal epithelial
barrier is breached and the gut microbiota invade. Despite current efforts in understanding …

Naegleria fowleri, or the “brain-eating amoeba,” is responsible for a rare, but lethal, infection
known as primary amoebic meningoencephalitis (PAM). Confirmed PAM cases have seen …

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infants and young
children. Although some clinical studies have speculated that tumor necrosis factor (TNF)-α …

Purpose: Contact lens wear can induce corneal parainflammation involving CD11c+ cell
responses (24 hours), γδ T cell responses (24 hours and 6 days), and IL-17-dependent …