Nucleus accumbens and impulsivity

K Basar, T Sesia, H Groenewegen… - Progress in …, 2010 - Elsevier
The multifaceted concept of impulsivity implies that different impulsivity aspects, mediated by
different neural processes, influence behavior at different levels. The nucleus accumbens …

The" two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

I Weiner - Psychopharmacology, 2003 - Springer
Rationale Latent inhibition (LI), namely, poorer performance on a learning task involving a
previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) …

Dissociable roles for the nucleus accumbens core and shell in regulating set shifting

SB Floresco, S Ghods-Sharifi, C Vexelman… - Journal of …, 2006 - Soc Neuroscience
The ability to behave in a flexible manner is an executive function mediated in part by
different regions of the prefrontal cortex. The present study investigated the role of two major …

[HTML][HTML] Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

JF Chen, DS Choi, RA Cunha - Neuropharmacology, 2023 - Elsevier
Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …

Double dissociation of the effects of selective nucleus accumbens core and shell lesions on impulsive‐choice behaviour and salience learning in rats

HHJ Pothuizen, AL Jongen‐Rêlo… - European Journal of …, 2005 - Wiley Online Library
The nucleus accumbens can be subdivided into at least two anatomically distinct
subregions: a dorsolateral 'core'and a ventromedial 'shell', and this distinction may extend to …

The pharmacology of latent inhibition as an animal model of schizophrenia

PC Moser, JM Hitchcock, S Lister, PM Moran - Brain Research Reviews, 2000 - Elsevier
The nature of the primary symptoms of schizophrenia and our lack of knowledge of its
underlying cause both contribute to the difficulty of generating convincing animal models of …

The switching model of latent inhibition: an update of neural substrates

I Weiner, J Feldon - Behavioural brain research, 1997 - Elsevier
Organisms exposed to a stimulus which has no significant consequences, show
subsequently latent inhibition (LI), namely, retarded conditioning to this stimulus. LI is …

Electrolytic lesions of the medial prefrontal cortex in rats disrupt performance on an analog of the Wisconsin Card Sorting Test, but do not disrupt latent inhibition …

D Joel, I Weiner, J Feldon - Behavioural brain research, 1997 - Elsevier
The effects of electrolytic lesions of the medial prefrontal cortex (mPFC) or its subregions
were investigated on two cognitive tests that may have relevance to the behavioral …

The effects of excitotoxic lesion of the medial prefrontal cortex on latent inhibition, prepulse inhibition, food hoarding, elevated plus maze, active avoidance and …

L Lacroix, LM Broersen, I Weiner, J Feldon - Neuroscience, 1998 - Elsevier
Latent inhibition is a measure of retarded conditioning to a previously presented
nonreinforced stimulus that is impaired in schizophrenic patients and in rats treated with …

The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

JA Gray, MH Joseph, DR Hemsley, AMJ Young… - Behavioural brain …, 1995 - Elsevier
Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned
stimulus is first presented a number of times without other consequence. Disruption of LI has …