Background Warfarin induced skin necrosis is a rare complication with a prevalence of 0· 01–
0· 1 per cent. It was first described in 1943. Methods A literature review was undertaken …

Protein C replacement therapy with a monoclonal antibody purified, virus inactivated protein
C concentrate was carried out in nine infants (three male, six female) with severe congenital …

The prothrombin time (PT) is one of the most important laboratory tests to determine the
functionality of the blood coagulation system. It is used in patient care to diagnose diseases …

Warfarin‐induced skin necrosis is a rare complication of therapy with warfarin or other
coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy …

The protein C anticoagulant pathway provides a mechanism for regulating the coagulation
process through the selective inactivation of factors Va and VIIIa. Recent studies have …

From the Center for Thrombosis ond Hemostosis ond the Division of Hemotology/Oncology
University of North Corolino ot Chopet Hitt, Chopet Hi [, NC, USA lntroduction hands are also …

Two patients developed catastrophic multicentric skin necrosis while receiving warfarin to
treat venous thromboembolism complicated by immune‐mediated heparin‐induced …

The protein C pathway has an important function in regulating and modulating blood
coagulation and ensuring patency of the microcirculation. Protein C deficiency leads to …

Anticoagulant-induced skin reactions appear as allergic or necrotic responses to vitamin K
antagonists or heparins. Cutaneous allergy has been reported with danaparoid sodium and …

Protein C (PC) is a vitamin K-dependent plasma protein that is structurally similar to other
coagulation factors such as prothrombin and Factor X. PC is converted to its active …