Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …

Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

The chemical and biological interest in this element and the molecules bearing selenium
has been exponentially growing over the years. Selenium, formerly designated as a toxin …

Trypanothione synthetase (TryS) catalyses the synthesis of N 1, N8-bis (glutathionyl)
spermidine (trypanothione), which is the main low molecular mass thiol supporting several …

The current drug treatments against protozoan parasitic diseases including Chagas,
malaria, leishmaniasis, and toxoplasmosis represent good examples of drug resistance …

Earlier evidences showed that diglycosyl diselenides are active against the infective stage of
African trypanosomes (top hits IC 50 0.5 and 1.5 μM) but poorly selective (selectivity index< …

Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …

Trypanosomes have a trypanothione redox metabolism that provides the reducing
equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx) …

In the search for a more effective chemotherapy for the treatment of Human African
Trypanosomiasis, a disease caused by the parasite Trypanosoma brucei, the development …

Searching for prospective agents against infectious diseases, four new ferrocenyl
derivatives,[M (L)(dppf) 4](PF 6), with M= Pd (II) or Pt (II), dppf= 1, 1′-bis …