Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Polyethylene terephthalate (PET) is the most widespread synthetic polyester, having been
utilized in textile fibers and packaging materials for beverages and food, contributing …

Attention-based models trained on protein sequences have demonstrated incredible
success at classification and generation tasks relevant for artificial-intelligence-driven …

Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Directed evolution has revolutionized biomolecular engineering by applying cycles of
mutation, amplification and selection to genes of interest (GOIs). However, classical directed …

Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …

The isomerization of xylose to xylulose is considered the most promising approach to initiate
xylose bioconversion. Here, phylogeny-guided big data mining, rational modification, and …

In addition to its value in the study of molecular evolution, ancestral sequence reconstruction
(ASR) has emerged as a useful methodology for engineering proteins with enhanced …

Increasing the temperature by just a few degrees may lead to structural perturbation or
unfolding of the protein and consequent loss of function. The concepts of flexibility and …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …