[HTML][HTML] Evaluation of synergism in drug combinations and reference models for future orientations in oncology
Current cancer therapy includes a variety of strategies that can comprise only one type of
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …
treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for …
Active mitochondrial respiration in cancer: a target for the drug
M Bedi, M Ray, A Ghosh - Molecular and Cellular Biochemistry, 2022 - Springer
The relative contribution of mitochondrial respiration and subsequent energy production in
malignant cells has remained controversial to date. Enhanced aerobic glycolysis and …
malignant cells has remained controversial to date. Enhanced aerobic glycolysis and …
Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
C Liu, W Zou, D Nie, S Li, C Duan, M Zhou, P Lai… - Cell metabolism, 2022 - cell.com
Our group has reported previously on the role of various members of the protein arginine
methyltransferase (PRMT) family, which are involved in epigenetic regulation, in the …
methyltransferase (PRMT) family, which are involved in epigenetic regulation, in the …
[HTML][HTML] Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in …
Despite considerable advances in cancer treatment, chemotherapy remains a cornerstone
in breast cancer therapy. Therefore, reducing chemoresistance and adverse effects of …
in breast cancer therapy. Therefore, reducing chemoresistance and adverse effects of …
Diosmetin exerts synergistic effects in combination with 5-fluorouracil in colorectal cancer cells
5-Fluorouracil (5-FU) is a chemotherapeutic medication commonly used to treat colorectal
cancer (CRC); however, the drug-associated adverse effects and toxicity have greatly …
cancer (CRC); however, the drug-associated adverse effects and toxicity have greatly …
Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil
Targeting bioactives selectively to diseased sites is one of the most challenging aspects of
cancer therapy. Herein, fabrication of colonic enzyme-responsive dextran based oligoester …
cancer therapy. Herein, fabrication of colonic enzyme-responsive dextran based oligoester …
The natural isoflavone Biochanin‐A synergizes 5‐fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid‐phase carcinoma model
Isoflavones are considered one of the most extensively studied plant‐derived
phytoestrogenic compounds. Of these, Biochanin A (Bio‐A), a natural isoflavone abundant …
phytoestrogenic compounds. Of these, Biochanin A (Bio‐A), a natural isoflavone abundant …
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway
Abstract Ginsenoside-Rh1 (Rh1) is a ginseng-derived compound that has been reported to
exert anticancer effects by regulating cell cycle arrest and apoptosis according to reactive …
exert anticancer effects by regulating cell cycle arrest and apoptosis according to reactive …
A review of twenty years of research on the regulation of signaling pathways by natural products in breast cancer
Breast cancer (BC) is the second leading cause of death among women, and it has become
a global health issue due to the increasing number of cases. Different treatment options …
a global health issue due to the increasing number of cases. Different treatment options …
Sp-bromobenzyl-glutathione cyclopentyl diester (BBGC) as novel therapeutic strategy to enhance trabectedin anti-tumor effect in soft tissue sarcoma preclinical …
F Pantano, S Simonetti, M Iuliani, MJ Guillen, C Cuevas… - Oncogene, 2024 - nature.com
Trabectedin, approved for the treatment of soft tissue sarcoma (STS), interferes with cell
division and genetic transcription processes. Due to its strong anti-tumor activity in only …
division and genetic transcription processes. Due to its strong anti-tumor activity in only …