Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?

M Awan, I Buriak, R Fleck, B Fuller, A Goltsev… - Regenerative …, 2020 - Taylor & Francis
Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since
the early history of cryopreservation. It has been used for decades in many thousands of cell …

The impact of cryopreservation on bone marrow-derived mesenchymal stem cells: a systematic review

S Bahsoun, K Coopman, EC Akam - Journal of translational medicine, 2019 - Springer
Mesenchymal stem cells (MSCs) represent an invaluable asset for the field of cell therapy.
Human Bone marrow-derived MSCs (hBM-MSCs) are one of the most commonly used cell …

Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model

AJ Joswig, A Mitchell, KJ Cummings, GJ Levine… - Stem cell research & …, 2017 - Springer
Background Intra-articular injection of mesenchymal stem cells (MSCs) is efficacious in
osteoarthritis therapy. A direct comparison of the response of the synovial joint to intra …

Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting

AL Rowland, D Miller, A Berglund… - Stem cells …, 2021 - academic.oup.com
Allogeneic mesenchymal stromal cells (MSCs) have been used clinically for decades,
without cross-matching, on the assumption that they are immune-privileged. In the equine …

Equine mesenchymal stem cells: properties, sources, characterization, and potential therapeutic applications

MB Gugjoo, GT Sharma - Journal of equine veterinary science, 2019 - Elsevier
Abstract Properties like sustained multiplication and self-renewal, and homing and
multilineage differentiation to undertake repair of the damaged tissues make stem cells the …

Quantitative assessment of the impact of cryopreservation on human bone marrow-derived mesenchymal stem cells: up to 24 h post-thaw and beyond

S Bahsoun, K Coopman, EC Akam - Stem cell research & therapy, 2020 - Springer
Background The effects of cryopreservation on human bone marrow-derived mesenchymal
stem cells (hBM-MSCs) are still ill-defined. In this study, a quantitative approach was …

Preparation technique affects recipient immune targeting of autologous mesenchymal stem cells

AL Rowland, ME Burns, GJ Levine… - Frontiers in veterinary …, 2021 - frontiersin.org
Fetal bovine serum (FBS) is used for MSC preparation in pre-clinical animal models and
veterinary applications, recently in US clinical trials, and for MSC products with current …

The impact of various culture conditions on human mesenchymal stromal cells metabolism

P Tonarova, K Lochovska, R Pytlik… - Stem cells …, 2021 - Wiley Online Library
In vitro and in vivo analyses are closely connected, and the reciprocal relationship between
the two comprises a key assumption with concern to the conducting of meaningful research …

Comparison of the characteristics of canine adipose tissue-derived mesenchymal stem cells extracted from different sites and at different passage numbers

KM Yaneselli, CP Kuhl, PB Terraciano… - Journal of …, 2018 - synapse.koreamed.org
Mesenchymal stem cells (MSCs) have desirable characteristics for use in therapy in animal
models and veterinary medicine, due to their capacity of inducing tissue regeneration and …

Effect of intra-ovarian injection of mesenchymal stem cells in aged mares

ST Grady, AE Watts, JA Thompson… - Journal of assisted …, 2019 - Springer
Purpose This study aims to determine if intra-ovarian injection of bone marrow–derived
mesenchymal stem cells (MSCs) improves or restores ovarian function in aged females …