Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

When animals walk overground, mechanical stimuli activate various receptors located in
muscles, joints and skin. Afferents from these mechanoreceptors project to neuronal …

The precision of skilled movement depends on sensory feedback and its refinement by local
inhibitory microcircuits. One specialized set of spinal GABAergic interneurons forms axo …

Chronic pain presents a major unmet clinical problem. The development of more effective
treatments is hindered by our limited understanding of the neuronal circuits underlying …

Developmental studies identified four classes (V0, V1, V2, V3) of embryonic interneurons in
the ventral spinal cord. Very little is known, however, about their adult phenotypes …

GABAergic interneurons are key elements in neural coding, but the mechanisms that
assemble inhibitory circuits remain unclear. In the spinal cord, the transfer of sensory signals …

Key points• Perception of normal bodily sensations relies on the precise regulation of
sensory information entering the dorsal horn of the spinal cord.• Inhibitory, axoaxonic …

The ability to sense and move within an environment are complex functions necessary for
the survival of nearly all species. The spinal cord is both the initial entry site for peripheral …

Spinal neurons and networks that generate rhythmic locomotor activity remain incompletely
defined, prompting the use of molecular biological strategies to label populations of neurons …

Background Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase
(SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in …