Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside
Despite impressive efforts invested in epigenetic research in the last 50 years, clinical
applications are still lacking. Only a few university hospital centers currently use epigenetic …
applications are still lacking. Only a few university hospital centers currently use epigenetic …
A paradigm shift in medicine: A comprehensive review of network-based approaches
Network medicine is a rapidly evolving new field of medical research, which combines
principles and approaches of systems biology and network science, holding the promise to …
principles and approaches of systems biology and network science, holding the promise to …
Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery
In this study, we integrate the outcomes of co-expression network analysis with the human
interactome network to predict novel putative disease genes and modules. We first apply the …
interactome network to predict novel putative disease genes and modules. We first apply the …
Network-based approaches to explore complex biological systems towards network medicine
Network medicine relies on different types of networks: from the molecular level of protein–
protein interactions to gene regulatory network and correlation studies of gene expression …
protein interactions to gene regulatory network and correlation studies of gene expression …
The TGF-β Family in Glioblastoma
I Golán-Cancela, L Caja - International Journal of Molecular Sciences, 2024 - mdpi.com
Members of the transforming growth factor β (TGF-β) family have been implicated in the
biology of several cancers. In this review, we focus on the role of TGFβ and bone …
biology of several cancers. In this review, we focus on the role of TGFβ and bone …
[HTML][HTML] In silico drug repurposing in COVID-19: A network-based analysis
The SARS-CoV-2 pandemic is a worldwide public health emergency. Despite the beginning
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
Key disease mechanisms linked to Alzheimer's disease in the entorhinal cortex
V Bottero, D Powers, A Yalamanchi, JP Quinn… - International journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a chronic, neurodegenerative brain disorder affecting millions of
Americans that is expected to increase in incidence with the expanding aging population …
Americans that is expected to increase in incidence with the expanding aging population …
Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated …
Y Wang, M Zhao, Y Zhang - Bioengineered, 2021 - Taylor & Francis
Immune cell infiltration (ICI) plays a pivotal role in the development of diabetic nephropathy
(DN). Evidence suggests that immune-related genes play an important role in the initiation of …
(DN). Evidence suggests that immune-related genes play an important role in the initiation of …
Identification of upregulated genes in glioblastoma and glioblastoma cancer stem cells using bioinformatics analysis
Glioblastoma (GBM) is the most common malignant brain tumor among adults. Cancer stem
cells (CSCs) are known to drive treatment resistance and recurrence. However, a few CSC …
cells (CSCs) are known to drive treatment resistance and recurrence. However, a few CSC …
Glucose and amino acid metabolic dependencies linked to stemness and metastasis in different aggressive cancer types
A Chisari, I Golán, S Campisano, C Gélabert… - Frontiers in …, 2021 - frontiersin.org
Malignant cells are commonly characterised by being capable of invading tissue, growing
self-sufficiently and uncontrollably, being insensitive to apoptosis induction and controlling …
self-sufficiently and uncontrollably, being insensitive to apoptosis induction and controlling …