The diversity of glycerophospholipid species in cellular membranes is immense and affects
various biological functions. Glycerol-3-phosphate acyltransferases (GPATs) and …

MBOAT7 is a protein anchored to endomembranes by several transmembrane domains. It
has a catalytic dyad involved in remodelling of phosphatidylinositol with polyunsaturated …

Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer.
Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those …

Lipids are important in multiple cellular functions, with most having structural or energy
storage roles. However, a small fraction of lipids exert bioactive roles through binding to G …

Advanced liver diseases account for approximately 2 million deaths annually worldwide.
Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial
disease and becoming the leading cause of liver-related morbidity and mortality. MASLD …

Acylation modifications play a central role in biological and physiological processes. Across
a range of biomolecules from phospholipids to triglycerides to proteins, introduction of a …

Highly unsaturated fatty acids (HUFAs) are fatty acids with more than three double bonds in
the molecule. Mammalian testes contain very high levels of omega-6 HUFAs compared with …

Background and Aims Polymorphisms near the membrane bound O-acyltransferase domain
containing 7 (MBOAT7) genes are associated with worsened nonalcoholic fatty liver …

Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder,
including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase …