Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …

Immune checkpoint blockade (ICB) is a promising treatment strategy for colorectal cancer
(CRC) patients. However, most CRC patients do not response well to ICB therapy …

This review examines the involvement of cytochrome P450 (CYP) enzymes in the formation
of reactive oxygen species in biological systems and discusses the possible involvement of …

Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …

Cytochrome P450s (CYPs) represent a large class of heme-containing enzymes that
catalyze the metabolism of multitudes of substrates both endogenous and exogenous. Until …

The concept of overexpression of individual forms of cytochrome P 450 enzymes in tumor
cells is now becoming well recognized. Indeed, a growing body of research highlights the …

Abstract Purpose: The cytochromes P450 (P450) are a multigene family of enzymes with a
central role in the oxidative metabolism of a wide range of xenobiotics, including anticancer …

Abstract Purpose: Cytochrome P 450 1B1 (CYP1B1), a dioxin inducible member of the CYP
supergene family, is overexpressed in various human malignancies including prostate …

Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs,
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …