Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …

Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline …

Electron cryomicroscopy can, in principle, determine the structures of most biological
molecules but is currently limited by access, specimen preparation difficulties, and cost. We …

G-protein-coupled receptors (GPCRs) are the target of> 30% of approved drugs. Despite
their popularity, many of the> 800 human GPCRs remain understudied. The Illuminating the …

The Kv1. 3 potassium channel is expressed abundantly on activated T cells and mediates
the cellular immune response. This role has made the channel a target for therapeutic …

The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

Imaging large fields of view at a high magnification requires tiling. Transmission electron
microscopes typically have round beam profiles; therefore, tiling across a large area is either …

HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is
mediated by the viral enzyme integrase and is blocked by integrase strand transfer inhibitors …

Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …

Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human
cancers. While significant effort has been invested in the development of synthetic TRPV6 …