Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …

The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

Protein accumulation and aggregation with a concomitant loss of proteostasis often
contribute to neurodegenerative diseases, and the ubiquitin–proteasome system plays a …

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

The ubiquitin–proteasome system (UPS) is the primary selective degradation system in the
nuclei and cytoplasm of eukaryotic cells, required for the turnover of myriad soluble proteins …

The proteasome has emerged as an intricate machine that has dynamic mechanisms to
regulate the timing of its activity, its selection of substrates, and its processivity. The 19 …

Although rates of protein degradation by the ubiquitin-proteasome pathway (UPS) are
determined by their rates of ubiquitination, we show here that the proteasome's capacity to …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …