Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy

Y Hattori, T Andoh, S Kawabata, N Hu… - Journal of radiation …, 2023 - academic.oup.com
Recently, boron neutron capture therapy (BNCT) has been attracting attention as a
minimally invasive cancer treatment. In 2020, the accelerator-based BNCT with L-BPA …

4-Borono-2-18F-fluoro-l-phenylalanine PET for boron neutron capture therapy-oriented diagnosis: overview of a quarter century of research

K Ishiwata - Annals of nuclear medicine, 2019 - Springer
10 B-Borono-2-18 F-fluoro-l-phenylalanine (18 F-FBPA) was developed for monitoring the
pharmacokinetics of 4-10 B-borono-l-phenylalanine (10 B-BPA) used in boron neutron …

Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism

T Nomoto, Y Inoue, Y Yao, M Suzuki, K Kanamori… - Science …, 2020 - science.org
In the current clinical boron neutron capture therapy (BNCT), p-boronophenylalanine (BPA)
has been the most powerful drug owing to its ability to accumulate selectively within cancers …

RGD peptide-conjugated dodecaborate with the Ga-DOTA complex: a preliminary study for the development of theranostic agents for boron neutron capture therapy …

K Mishiro, S Imai, Y Ematsu, K Hirose… - Journal of Medicinal …, 2022 - ACS Publications
A boron neutron capture therapy (BNCT) system, using boron-10-introduced agents coupled
with companion diagnostics, is anticipated as a promising cancer theranostic. Thus, this …

Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy

R Kawasaki, H Hirano, K Yamana, H Isozaki… - … , Biology and Medicine, 2023 - Elsevier
Boron neutron capture therapy shows is a promising approach to cancer therapy, but the
delivery of effective boron agents is challenging. To address the requirements for efficient …

Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

AM Hughes - Expert Reviews in Molecular Medicine, 2022 - cambridge.org
Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on
the administration of boron carriers incorporated preferentially by tumour cells, followed by …

Evaluation of a Novel Boron-Containing α-d-Mannopyranoside for BNCT

T Tsurubuchi, M Shirakawa, W Kurosawa, K Matsumoto… - Cells, 2020 - mdpi.com
Boron neutron capture therapy (BNCT) is a unique anticancer technology that has
demonstrated its efficacy in numerous phase I/II clinical trials with boronophenylalanine …

Accelerator-based boron neutron capture therapy for malignant glioma: A pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal …

E Zavjalov, A Zaboronok, V Kanygin… - … journal of radiation …, 2020 - Taylor & Francis
Purpose: To evaluate the efficacy of boron neutron capture therapy (BNCT) for a heterotopic
U87 glioblastoma model in SCID mice using boron phenylalanine (BPA), sodium …

Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy

T Watanabe, Y Sanada, Y Hattori… - Journal of Radiation …, 2023 - academic.oup.com
Boron neutron capture therapy (BNCT) is a binary cancer therapy that involves boron
administration and neutron irradiation. The nuclear reaction caused by the interaction of …

Diagnostic and theranostic technologies used in boron neutron capture therapy–A brief review

P Coghi, T Fazal, NS Hosmane, Y Zhu - Inorganic Chemistry …, 2024 - Elsevier
Boron neutron capture therapy (BNCT) is a highly targeted, selective and effective technique
to cure various types of cancers, with less harms to the healthy cells. In principle, BNCT …