Background The clinical research enterprise is not producing the evidence decision makers
arguably need in a timely and cost effective manner; research currently involves the use of …

Stakeholders in healthcare are increasingly turning to real world evidence (RWE) to inform
their decisions, alongside evidence from randomized controlled trials. RWE is generated by …

Pragmatic clinical trials (PCTs) are research investigations embedded in health care settings
designed to increase the efficiency of research and its relevance to clinical practice. The …

Pragmatic clinical trials are conducted under the real-world conditions of clinical care
delivery. As a result, these trials yield findings that are highly generalizable to the …

Background: Emerging evidence that meaningful relationships with knowledge users are a
key predictor of research use has led to promotion of partnership approaches to health …

The increasing prevalence of multimorbidity in the United States and the rest of the world
poses problems for patients and for health care providers, care systems, and policy. After …

Electronic health records (EHRs) can be a major tool in the quest to decrease costs and
timelines of clinical trial research, generate better evidence for clinical decision making, and …

Electronic health records have the potential to improve the care of patients with chronic
medical conditions. CKD provides a unique opportunity to show this potential: the disease is …

Background Data from clinical trials to inform practice in maintenance hemodialysis are
limited. Incorporating randomized trials into dialysis clinical care delivery should help …

Implementation Science (IS) studies the adoption of interventions into clinical practice,
taking into account real-world populations and clinical settings. While randomized control …