Fatty acid synthase (FAS), polyketide synthase (PKS), and nonribosomal peptide synthetase
(NRPS) modular biosynthetic enzymes are responsible for the production of a multitude of …

The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl
carrier in all organisms, have long been regarded as excellent targets for the development of …

Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an
extracellular supply of pantothenate (vitamin B5) and is susceptible to inhibition by …

Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin precursor
of the essential cofactor and universal acyl carrier coenzyme A. A recent study has …

N‐substituted pantothenamides are analogues of pantothenic acid, the vitamin precursor of
CoA, and constitute a class of well‐studied bacterial growth inhibitors that show potential as …

The emergence of resistance against current antibiotics calls for the development of new
compounds to treat infectious diseases. Synthetic pantothenamides are pantothenate …

N-Substituted pantothenamides (PanAms) are pantothenate analogues with up to
nanomolar potency against blood-stage Plasmodium falciparum (the most virulent species …

In the absence of an effective vaccine against malaria suitable for widespread deployment,
the control of this lethal infectious disease relies heavily on antimalarial chemotherapies …

Malaria kills more than half a million people each year. There is no vaccine, and recent
reports suggest that resistance is developing to the antimalarial regimes currently …

As a key precursor of coenzyme A (CoA) biosynthesis, pantothenic acid has proven to be a
useful backbone to elaborate probes of this biosynthetic pathway, study CoA-utilizing …