Simple Summary The bone marrow (BM) microenvironment plays a crucial role in
pathogenesis of multiple myeloma (MM), and delineation of the intracellular signaling …

Multiple myeloma (MM) is considered to be the second most common blood malignancy and
it is characterized by abnormal proliferation and an accumulation of malignant plasma cells …

Multiple myeloma (MM) is characterized by multiple relapse and, despite the introduction of
novel therapies, the disease becomes ultimately drug-resistant. The tumor …

Myeloma is characterized by bone lesions, which are related to both an increased osteoclast
activity and a defect in the differentiation of medullary mesenchymal stem cells (MSCs) into …

Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic
precursor condition that precedes nearly all cases of multiple myeloma (MM)[1] and is …

Background Monoclonal gammopathy of undetermined significance (MGUS) is associated
with renal dysfunction, inflammation, and increased cardiovascular mortality, but the …

Multiple myeloma (MM) is a disease of clonally differentiated plasma cells. MM is almost
always preceded by precursor conditions, monoclonal gammopathy of unknown …

While the link between serum proteins and cancer has been studied in an effort to enable
early-stage cancer detection, factors that might perturb this link has been poorly understood …

Multiple myeloma (MM) accounts for about 10% of hematologic malignancies, and it is the
second most frequent hematologic neoplasm after lymphomas. The exact etiology of MM is …

There is a paucity of data on the cardiovascular implications of monoclonal gammopathy of
undetermined significance, especially among hospitalized patients. Our study aimed to …