ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

Abstract Phosphoinositide 3-kinases (PI3Ks) regulate numerous biological processes,
including cell growth, differentiation, survival, proliferation, migration and metabolism. In the …

Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the …

The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase
families found in the human genome. Members of these kinase families function …

Activation of Jak tyrosine kinases through hematopoietic cytokine receptors occurs as a
consequence of ligand-induced aggregation of receptor-associated Jaks and their …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

Cytoplasmic protein‐tyrosine kinases (PTKs) are enzymes involved in transducing a vast
number of signals in metazoans. The importance of the Tec family of kinases was …

▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the
B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have …

The Arp2/3 complex can be independently activated to initiate actin polymerization by the
VCA domain of WASP family members and by the acidic N-terminal and F-actin-binding …

Protein–protein interactions are essential in every aspect of cellular activity. Multiprotein
complexes form and dissociate constantly in a specifically tuned manner, often by conserved …