Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
[HTML][HTML] AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
J Díaz-Alonso, RA Nicoll - Neuropharmacology, 2021 - Elsevier
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors
S Boudkkazi, J Schwenk, N Nakaya, A Brechet… - Neuron, 2023 - cell.com
Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor
AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength
Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …
the strength of communication between neurons in the brain. The unique subsynaptic …
mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function
N Scheefhals, M Westra, HD MacGillavry - Nature communications, 2023 - nature.com
The unique perisynaptic distribution of postsynaptic metabotropic glutamate receptors
(mGluRs) at excitatory synapses is predicted to directly shape synaptic function, but …
(mGluRs) at excitatory synapses is predicted to directly shape synaptic function, but …
MINFLUX fluorescence nanoscopy in biological tissue
T Moosmayer, KA Kiszka, V Westphal, JK Pape… - Proceedings of the …, 2024 - pnas.org
Optical imaging access to nanometer-level protein distributions in intact tissue is a highly
sought-after goal, as it would provide visualization in physiologically relevant contexts …
sought-after goal, as it would provide visualization in physiologically relevant contexts …
Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific
Heterotetrameric glutamate receptors are essential for the development, function, and
plasticity of spine synapses but how they are organized to achieve this is not known. Here …
plasticity of spine synapses but how they are organized to achieve this is not known. Here …
The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65
CH Jiang, M Wei, C Zhang… - Proceedings of the …, 2021 - National Acad Sciences
Long-term potentiation (LTP) has long been considered as an important cellular mechanism
for learning and memory. LTP expression involves NMDA receptor-dependent synaptic …
for learning and memory. LTP expression involves NMDA receptor-dependent synaptic …
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
Regulation of synaptic neurotransmitter receptor content is a fundamental mechanism for
tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation …
tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation …