Self-healing injectable hydrogels for tissue regeneration

P Bertsch, M Diba, DJ Mooney… - Chemical …, 2022 - ACS Publications
Biomaterials with the ability to self-heal and recover their structural integrity offer many
advantages for applications in biomedicine. The past decade has witnessed the rapid …

[HTML][HTML] Recent advances in long-acting drug delivery systems for anticancer drug

C Pacheco, A Baiao, T Ding, W Cui… - Advanced Drug Delivery …, 2023 - Elsevier
The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether
dealing with small molecules or biopharmaceuticals, after systemic administration, small …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

Injectable hydrogels for personalized cancer immunotherapies

N Mohaghegh, A Ahari, F Zehtabi, C Buttles, S Davani… - Acta Biomaterialia, 2023 - Elsevier
The field of cancer immunotherapy has shown significant growth, and researchers are now
focusing on effective strategies to enhance and prolong local immunomodulation. Injectable …

Intraparticle double‐scattering‐decoded sonogenetics for augmenting immune checkpoint blockade and CAR‐T therapy

D Wang, M Zhang, Y Zhang, G Qiu, J Chen… - Advanced …, 2022 - Wiley Online Library
Genetically arming new chimeric antigen receptors (CARs) on T cells is a prevalent method
to fulfill CAR‐T immunotherapy. However, this approach fails to completely address the poor …

Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma

U Uslu, T Da, CA Assenmacher, J Scholler… - Science …, 2023 - science.org
Incomplete surgery of solid tumors is a risk factor for primary treatment failure. Here, we have
investigated whether chimeric antigen receptor T cells (CARTs) could be used as an …

Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

K Adu-Berchie, JM Brockman, Y Liu, TW To… - Nature …, 2023 - nature.com
Although adoptive T cell therapy provides the T cell pool needed for immediate tumor
debulking, the infused T cells generally have a narrow repertoire for antigen recognition and …

Recent advances in biomaterial-boosted adoptive cell therapy

Y Xue, J Che, X Ji, Y Li, J Xie, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Adoptive immunotherapies based on the transfer of functional immune cells hold great
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …

[HTML][HTML] Rationally designed approaches to augment CAR-T therapy for solid tumor treatment

C Zhu, Q Wu, T Sheng, J Shi, X Shen, J Yu, Y Du… - Bioactive Materials, 2024 - Elsevier
Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible
therapeutic advancements for B cell malignancy treatment. However, its therapeutic validity …

Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy

Q Shang, Y Dong, Y Su, F Leslie, M Sun… - Advanced Drug Delivery …, 2022 - Elsevier
Cancer immunotherapy, which reprograms a patient's own immune system to eradicate
cancer cells, has been demonstrated as a promising therapeutic strategy clinically. Immune …