The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in
eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co …

Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …

To fully understand the regulation of gene expression, it is critical to quantitatively define
whether and how RNA-binding proteins (RBPs) discriminate between alternative binding …

The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with
important roles in multiple aspects of nucleic acid metabolism, including the packaging of …

Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse
affinities and specificities towards target RNAs. These proteins play a crucial role in almost …

Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …

RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some
are reported to be involved in human tumorigenesis. However, little is known about the …