Integrating gene annotation with orthology inference at scale

BM Kirilenko, C Munegowda, E Osipova, D Jebb… - Science, 2023 - science.org
Annotating coding genes and inferring orthologs are two classical challenges in genomics
and evolutionary biology that have traditionally been approached separately, limiting …

Understanding the evolution of immune genes in jawed vertebrates

M Vinkler, SR Fiddaman, M Těšický… - Journal of …, 2023 - academic.oup.com
Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize
defence against pathogens within a given environment. Recent advances in genetics …

Host control and the evolution of cooperation in host microbiomes

C Sharp, KR Foster - Nature Communications, 2022 - nature.com
Humans, and many other species, are host to diverse symbionts. It is often suggested that
the mutual benefits of host-microbe relationships can alone explain cooperative evolution …

Pangolins lack IFIH1/MDA5, a cytoplasmic RNA sensor that initiates innate immune defense upon coronavirus infection

H Fischer, E Tschachler, L Eckhart - Frontiers in immunology, 2020 - frontiersin.org
Zoonotic infections are an imminent threat to human health. Pangolins were recently
identified as carriers and intermediate hosts of coronaviruses. Previous research has shown …

Convergent and lineage-specific genomic differences in limb regulatory elements in limbless reptile lineages

JG Roscito, K Sameith, BM Kirilenko, N Hecker… - Cell reports, 2022 - cell.com
Loss of limbs evolved many times in squamate reptiles. Here we investigated the genomic
basis of convergent limb loss in reptiles. We sequenced the genomes of a closely related …

Parallel decay of vision genes in subterranean water beetles

BL Langille, SM Tierney, T Bertozzi… - Molecular Phylogenetics …, 2022 - Elsevier
In the framework of neutral theory of molecular evolution, genes specific to the development
and function of eyes in subterranean animals living in permanent darkness are expected to …

Diversified mammalian visual adaptations to bright-or dim-light environments

Y Gai, R Tian, F Liu, Y Mu, L Shan… - Molecular Biology …, 2023 - academic.oup.com
Photic niche shifts of mammals are associated with changing visual capabilities, primarily
mediated by three visual pigments, two (SWS1 and M/LWS) of them for color vision and …

Natural selection directing molecular evolution in vertebrate viral sensors

B Melepat, T Li, M Vinkler - Developmental & Comparative Immunology, 2024 - Elsevier
Diseases caused by pathogens contribute to molecular adaptations in host immunity. Variety
of viral pathogens challenging animal immunity can drive positive selection diversifying …

Dynamic evolution of avian RNA virus sensors: Repeated loss of RIG-I and RIPLET

V Krchlíková, T Hron, M Těšický, T Li, L Ungrová… - Viruses, 2022 - mdpi.com
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5
(MDA5) are key RNA virus sensors belonging to the RIG-I-like receptor (RLR) family. The …

Adaptation and cryptic pseudogenization in penguin toll-like receptors

SR Fiddaman, M Vinkler, SG Spiro… - Molecular Biology …, 2022 - academic.oup.com
Penguins (Sphenisciformes) are an iconic order of flightless, diving seabirds distributed
across a large latitudinal range in the Southern Hemisphere. The extensive area over which …