The older population consisting of persons aged 65 years or older is the fastest-growing
population group and also the major consumer of pharmaceutical products. Due to the …

There is no refuting that America's population is growing older: for the first time in US history,
by 2034 older adults (defined as> 65 years of age) are projected to outnumber children …

Aims This study aims to develop and verify a physiologically based pharmacokinetic (PBPK)
population model for the Chinese geriatric population in Simcyp. Methods Firstly …

Introduction Drug-drug interaction (DDI) is one of the major concerns for the clinical use of
NOACs in the older adults considering that coexistence of multiple diseases and comorbidity …

The challenges of drug development in pediatric, pregnant and geriatric populations are a
worldwide concern shared by regulatory authorities, pharmaceutical companies, and …

Drug-related adverse events are higher in older patients than in non-older patients,
increasing the risk of medication and reducing compliance. Aging is accompanied by a …

The objective of this study was to evaluate bilastine dosing recommendations in older adults
and overcome the limitation of insufficient data from phase I studies in this underrepresented …

Medication therapy in older adults is complicated by the frequent presence of comorbidity
that requires coadministration of multiple therapeutic agents. This need for polypharmacy …

Pharmacology involves not only pharmacokinetics but also pharmacodynamics and the
principles affecting the proper selection, dosing, and monitoring of medications. Medications …

Peripheral infections induce prolonged and exaggerated neuroinflammatory responses in
the aged brain that result in cognitive impairment, neuropsychiatric complications and …