Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an
acute deterioration of liver function in patients with cirrhosis, which is usually associated with …

BACKGROUND & AIMS: Patients with cirrhosis hospitalized for an acute decompensation
(AD) and organ failure are at risk for imminent death and considered to have acute-on …

Context Infection is a major cause of morbidity and mortality in intensive care units (ICUs)
worldwide. However, relatively little information is available about the global epidemiology …

Acute-on-chronic liver failure (ACLF) is an increasingly recognized distinct disease entity
encompassing an acute deterioration of liver function in patients with chronic liver disease. 1 …

Objectives: We evaluated the respective influence of the causative pathogen and infection
site on hospital mortality from severe sepsis related to community-, hospital-, and intensive …

Purpose The aim of the study was to determine whether C-reactive protein (CRP),
procalcitonin (PCT), and d-dimer (DD) are markers of mortality in patients admitted to the …

Objective To develop a decision support system to identify patients at high risk for
hyperlactatemia based upon routinely measured vital signs and laboratory studies. Materials …

Objective: In an effort to improve upon the traditional sepsis syndrome definitions, the
predisposition, infection, response, organ dysfunction (PIRO) model was proposed to better …

Objective: To analyze serial biomarkers of the persistent inflammation, immunosuppression,
and catabolism syndrome (PICS) to gain insight into the pathobiology of chronic critical …

Objective: To generate and validate an initial version of the predisposition, insult/infection,
response, and organ dysfunction (PIRO) staging model for risk stratification in severe sepsis …