Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Immunosuppressive medications are widely used to treat patients with neoplasms,
autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin …

Calcineurin inhibitors (CNI), including cyclosporine A (CsA) and tacrolimus (TAC), are
cornerstones of immunosuppressive therapy in solid organ transplant recipients. While …

The development of new treatments for heart failure lack animal models that encompass the
increasingly heterogeneous disease profile of this patient population. This report provides …

Mitochondria from different organisms can undergo a sudden process of inner membrane
unselective leakiness to molecules known as the mitochondrial permeability transition …

The sarcoplasmic reticulum (SR) plays the key role in cardiac function as the major source of
Ca2+ that activates cardiomyocyte contractile machinery. Disturbances in finely-tuned SR …

Background: Concentric and eccentric cardiac hypertrophy are associated with pressure
and volume overload, respectively, in cardiovascular disease both conferring an increased …

Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca2+) handling,
energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte …

The amount and timing of Ca 2+ release from the sarcoplasmic reticulum (SR) during
cardiac cycle are the main determinants of cardiac contractility. Reversible phosphorylation …

Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic
dysfunction and multiple comorbidities. The number of patients is continuously increasing …