Abstract H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the
disialoganglioside GD2 (ref.). Chimeric antigen receptor-modified T cells targeting GD2 …

Simple Summary Diffuse midline gliomas are rare tumors of childhood characterized by a
midline location, a diffuse-infiltrative growth pattern, and newly described genetic and …

Pediatric high-grade gliomas are a devastating subset of brain tumors, characterized by their
aggressive pathophysiology and limited treatment options. Among them, H3 K27-altered …

Simple Summary Intramedullary primary spinal cord tumors represent a heterogeneous
group of very rare tumors. In cases of recurrence or high-grade tumors, radiotherapy …

Abstract H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the GD2
disialoganglioside and chimeric antigen receptor modified T-cells targeting GD2 (GD2 …

Diffuse midline glioma, H3 K27-altered (DMG-H3 K27) is an aggressive group of diffuse
gliomas that predominantly occurs in pediatric patients, involves midline structures, and …

Abstract H3 K27M-altered diffuse midline gliomas (DMGs) are highly malignant tumours that
arise in the midline structures of the CNS. Most DMGs carry an H3 K27M-mutation in one of …

Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201
Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201 J …

Large-scale sequencing led to the identification of driver molecular alterations such as
FGFR1 and BRAF in occasional diffuse midline gliomas (DMGs) H3K27-mutant but their …

Fewer than 10% of children with diffuse midline glioma (DMG) survive 2 years from
diagnosis. Radiation therapy remains the cornerstone of treatment and there are no …