Neuronal circuits for fear and anxiety
Decades of research has identified the brain areas that are involved in fear, fear extinction,
anxiety and related defensive behaviours. Newly developed genetic and viral tools …
anxiety and related defensive behaviours. Newly developed genetic and viral tools …
Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour
Research on defensive behaviour in mammals has in recent years focused on elicited
reactions; however, organisms also make active choices when responding to danger. We …
reactions; however, organisms also make active choices when responding to danger. We …
Fear generalization and anxiety: behavioral and neural mechanisms
JE Dunsmoor, R Paz - Biological psychiatry, 2015 - Elsevier
Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …
conditioning models elegantly describe how animals learn which stimuli in the environment …
[HTML][HTML] The ecology of human fear: survival optimization and the nervous system
We propose a Survival Optimization System (SOS) to account for the strategies that humans
and other animals use to defend against recurring and novel threats. The SOS attempts to …
and other animals use to defend against recurring and novel threats. The SOS attempts to …
Diverging neural pathways assemble a behavioural state from separable features in anxiety
Behavioural states in mammals, such as the anxious state, are characterized by several
features that are coordinately regulated by diverse nervous system outputs, ranging from …
features that are coordinately regulated by diverse nervous system outputs, ranging from …
The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research
AS Fox, AJ Shackman - Neuroscience letters, 2019 - Elsevier
Anxiety disorders impose a staggering burden on public health, underscoring the need to
develop a deeper understanding of the distributed neural circuits underlying extreme fear …
develop a deeper understanding of the distributed neural circuits underlying extreme fear …
More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans-Biological, experiential, temperamental factors, and …
TB Lonsdorf, CJ Merz - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Why do only some individuals develop pathological anxiety following adverse events? Fear
acquisition, extinction and return of fear paradigms serve as experimental learning models …
acquisition, extinction and return of fear paradigms serve as experimental learning models …
The neurobiology of fear generalization
The generalization of fear memories is an adaptive neurobiological process that promotes
survival in complex and dynamic environments. When confronted with a potential threat, an …
survival in complex and dynamic environments. When confronted with a potential threat, an …
Implications of memory modulation for post-traumatic stress and fear disorders
RG Parsons, KJ Ressler - Nature neuroscience, 2013 - nature.com
Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are
consistent with an uncontrollable state of fear. Their development involves heredity, previous …
consistent with an uncontrollable state of fear. Their development involves heredity, previous …
Extending the amygdala in theories of threat processing
The central extended amygdala is an evolutionarily conserved set of interconnected brain
regions that play an important role in threat processing to promote survival. Two core …
regions that play an important role in threat processing to promote survival. Two core …