Objective Liver fibrosis and subsequent cirrhosis is a major cause of death worldwide, but
few effective antifibrotic therapies are reported. Whey-hydrolyzed peptide (WHP), a major …

Background The changes of lipid metabolism have been implicated in the development of
many tumors, but its role in breast invasive carcinoma (BRCA) remains to be fully …

Cisplatin (CIS)-mediated nephrotoxicity is induced via transforming growth factor-beta (TGF-
β) and TGF-β-activated kinase (TAK1). TGF-β and TAK1 are known to interact with …

Objectives This randomized, double-blind, placebo-controlled clinical trial aimed to
prospectively examine the effect of pentoxifylline (PTX) on hypoxia-inducible factor-2 alpha …

Background/purpose Biliary atresia and other liver biliary obstructions are relevant
conditions in pediatric surgery due to their progression to biliary cirrhosis and indication for …

Renal ischemia-reperfusion injury (IRI) induces local inflammation leading to kidney
damage. Since pentoxifylline (PTX) and steroids have distinct immunomodulatory …

Background: Hydroxyapatite (HAP), as a common biomaterial in bone tissue engineering,
can be fabricated in combination with other osteogenic agents. Pentoxifylline (PTX) is …

血管内皮生长因子(vascular endothelial growth factor, VEGF), 作为一种多功能因子,
在组织细胞分化成熟的过程中, 发挥着很大的作用. 不论是在术后促进肝细胞再生 …

Background: Actually, no specific treatment has been endorsed by FDA for non-alcoholic
steatohepatitis (NASH). The present research aimed to evaluate the efficacy of PTX on …

Background: Alterations in lipid metabolism have been implicated in the development of
many 14 tumors. However, the contribution of different lipid metabolism pathways to Breast …