ABSTRACT Human Mesenchymal Stem Cells, hMSCs, were first named over 25 years ago
with the “stem cell” nomenclature derived from the fact that we and others could cause these …

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

Lack of affordable technologies for delivering microRNAs and siRNAs into cells on a large
scale has hindered our efforts to rapidly parse through hundreds of dysregulated …

Mesenchymal stem cells, which are poorly immunogenic and have potent
immunosuppressive activities, have emerged as promising cellular therapeutics for the …

Long-term lentiviral transduction of human mesenchymal stem cells (hMSCs) greatly
enhances the usefulness of these cells. However, such transduction currently requires the …

Abstract Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds
many of the proteins essential for cancer development. CCT is expressed in diverse cancers …

Genetic engineering of mesenchymal stromal cells (MSCs) is a tool widely used to explore
MSC properties in vitro and in vivo. Lentiviral infection with the use of polycations as an …

Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to
perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In …

Lentiviral vectors have emerged as an efficient, safe therapeutic tool for gene therapy based
on hematopoietic stem cells (HSCs) or T cells. However, the monitoring of transduced cells …

Increasing evidence supports that mesenchymal stromal/stem cells (MSCs) may represent
the target cell for sarcoma development. Although different sarcomas have been modeled in …