Combinatorial phage library is a powerful research tool for high-throughput screening of
protein interactions. Of all available molecular display techniques, phage display has proven …

Over the last two decades, nanobodies or single-domain antibodies have found their way in
research, diagnostics, and therapy. These antigen-binding fragments, derived from Camelid …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Introduction: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful
methodology to study protein dynamics, protein folding, protein-protein interactions, and …

Highlights•Hydrogen/deuterium exchange mass spectrometry (HDX-MS) technology for
assessment of higher order structure of protein therapeutics.•Methodology: global HDX-MS …

Following viral infection, viral antigens bind specifically to receptors on the surface of
lymphocytes thereby activating adaptive immunity in the host. An epitope, the smallest …

Currently licensed glycoconjugate vaccines are composed of a carbohydrate moiety
covalently linked to a protein carrier. Polysaccharides are T-cell independent antigens able …

Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …

Viral subunit vaccines often contain immunodominant non-neutralizing epitopes that divert
host immune responses. These epitopes should be eliminated in vaccine design, but there …

Differential hydrogen exchange-mass spectrometry (HX-MS) measurements are valuable for
identification of differences in the higher order structures of proteins. Typically, the data sets …