Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …

Significance: Cancer cells that are resistant to radiation and chemotherapy are a major
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …

Epidemiological studies show that maternal diabetes is associated with an increased risk of
autism spectrum disorders (ASDs), although the detailed mechanisms remain unclear. The …

Because of the increased insight into the biological role of hydrogen peroxide (H 2 O 2)
under physiological and pathological conditions and the role it presumably plays in the …

Previous studies have indicated that autophagy plays a critical role in spinal cord injury
(SCI), including traumatic spinal cord injury (TSCI) and ischemia-reperfusion spinal cord …

Symptomatic normal tissue injury is a common side effect following definitive therapeutic
radiation and chemotherapy treatment for a variety of malignancies. These cancer therapy …

Spinal cord ischemia/reperfusion (SCI/R) injury is a devastating complication usually
occurring after thoracoabdominal aortic surgery. However, it remains unsatisfactory for its …

The excessive production of various reactive oxidant species over endogenous antioxidant
defense mechanisms leads to the development of a state of oxidative stress, with serious …