Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …

Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at
the cell cortex or in association with other cytoskeletal proteins, such as actin or …

Anti‐angiogenic therapy has long been considered a promising strategy for solid cancers.
Intrinsic resistance to hypoxia is a major cause for the failure of anti‐angiogenic therapy, but …

How cells move is a fundamental biological question. The directionality of adherent
migrating cells depends on the assembly and disassembly (turnover) of focal adhesions …

Septins are involved in many important cellular processes, and septin dysfunction has been
implicated in various pathologies, such as cancer. Like other components of the …

Septins are cytoskeletal proteins conserved from algae and protists to mammals. A unique
feature of septins is their presence as heteromeric complexes that polymerize into filaments …

Background Excessive extracellular matrix deposition and increased stiffness are typical
features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal …