Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

There has been considerable progress in elucidating the molecular mechanisms that
contribute to memory formation and the generation of circadian rhythms. However, it is not …

Recent progress in genome-wide expression analysis has identified hundreds of circadian
genes not only in the suprachiasmatic nucleus (the mammalian master clock) but also in …

Surprisingly, in our modern 24/7 society, there is scant information on the impact of
developmental chronodisruption like the one experienced by shift worker pregnant women …

In the adult mammal the circadian system, which allows predictive adaptation to daily
environmental changes, comprises peripheral oscillators in most tissues, commanded by the …

Within the last few decades, melatonin has increasingly emerged in clinical oncology as a
naturally occurring bioactive molecule with substantial anticancer properties and a …

Circadian rhythmicity is a fundamental characteristic of organisms, which helps ensure that
vital functions occur in an appropriate and precise temporal sequence and in accordance …

The hormone melatonin is synthesized from serotonin by two enzymatic reactions (AANAT
and ASMT/HIOMT) in the pineal gland following a circadian rhythm with low levels during …

Sudden cardiac and cerebral events are most common in the morning. A fundamental
question is whether these events are triggered by the increase in physical activity after …

Internal temporal organisation properly synchronised to the environment is crucial for health
maintenance. This organisation is provided at the cellular level by the molecular clock, a …