Emerging concepts in congenital cytomegalovirus

MH Pesch, MR Schleiss - Pediatrics, 2022 - publications.aap.org
Over a century of research has focused on improving our understanding of congenital
cytomegalovirus (cCMV), yet it remains the most common congenital infection in the United …

[HTML][HTML] Maternal respiratory viral infections during pregnancy and offspring's neurodevelopmental outcomes: A systematic review

N San Martín-González, Á Castro-Quintas… - Neuroscience & …, 2023 - Elsevier
Maternal infections during pregnancy, as cytomegalovirus and zika, have been consistently
associated with severe newborn neurodevelopmental conditions, mainly related to vertical …

Implementation of pooled saliva tests for universal screening of cCMV infection

L Merav, N Ofek Shlomai, E Oiknine-Djian, O Caplan… - Nature Medicine, 2024 - nature.com
Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to
neurodevelopmental disabilities. Universal newborn infant screening of cCMV has been …

Secondary prevention of congenital cytomegalovirus infection with valacyclovir following maternal primary infection in early pregnancy

V Faure‐Bardon, J Fourgeaud… - … in Obstetrics & …, 2021 - Wiley Online Library
Objective Cytomegalovirus (CMV) maternal primary infection (MPI) in early pregnancy is the
main risk factor for congenital CMV (cCMV) infection with long‐term sequelae. Our aim was …

Cytomegalovirus infection and inflammation in developing brain

F Krstanović, WJ Britt, S Jonjić, I Brizić - Viruses, 2021 - mdpi.com
Human cytomegalovirus (HCMV) is a highly prevalent herpesvirus that can cause severe
disease in immunocompromised individuals and immunologically immature fetuses and …

Outcome of pregnancies with recent primary cytomegalovirus infection in first trimester treated with hyperimmunoglobulin: observational study

KO Kagan, M Enders, M Hoopmann… - … in Obstetrics & …, 2021 - Wiley Online Library
Objective To examine the efficacy of hyperimmunoglobulin (HIG) treatment in women with a
recent primary cytomegalovirus (CMV) infection up to 14 weeks' gestation. Methods This is …

The role of congenital cytomegalovirus infection in adverse birth outcomes: a review of the potential mechanisms

A Njue, C Coyne, AV Margulis, D Wang, MA Marks… - Viruses, 2020 - mdpi.com
Human cytomegalovirus (CMV) is a major cause of nonhereditary adverse birth outcomes,
including hearing and visual loss, neurologic deficits, and intrauterine growth retardation …

Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection …

M Leruez-Ville, C Chatzakis, D Lilleri… - The Lancet Regional …, 2024 - thelancet.com
Congenital cytomegalovirus (cCMV) infection carries a significant burden with a 0.64%
global prevalence and a 17–20% chance of serious long-term effects in children. Since the …

Pregnancy-related extracellular vesicles revisited

CE Condrat, VN Varlas, F Duică, P Antoniadis… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are small vesicles ranging from 20–200 nm to 10 μm in diameter
that are discharged and taken in by many different types of cells. Depending on the nature …

[HTML][HTML] Treatment with valacyclovir during pregnancy for prevention of congenital cytomegalovirus infection: a real-life multicenter Italian observational study

L Zammarchi, LR Tomasoni, G Liuzzi… - American Journal of …, 2023 - Elsevier
BACKGROUND Valacyclovir is the only treatment demonstrated to be effective for the
prevention of vertical transmission of cytomegalovirus within a clinical randomized, placebo …