Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …

Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …

Despite advances in four-factor (4F)-induced reprogramming (4FR) in vitro and in vivo, how
4FR interconnects with senescence remains largely under investigated. Here, using genetic …

Müller glia, as prominent glial cells within the retina, plays a significant role in maintaining
retinal homeostasis in both healthy and diseased states. In lower vertebrates like zebrafish …

Why biological age is a major risk factor for many of the most important human diseases
remains mysterious. We know that as organisms age, stem cell pools are exhausted while …

Plant protoplasts provide a starting material to induce pluripotent cell masses in vitro
competent for tissue regeneration. Dedifferentiation is associated with large-scale chromatin …

Purpose. The exact effects of histone deacetylase 3 (HDAC3) inhibition in DR related retinal
ganglion cells (RGCs) death remained unclear. This study is aimed at detecting the …

视网膜神经元受损和丢失是视觉系统神经退行性疾病的特征, 可能造成多种致盲性眼病.
利用外源性和内源性干细胞实现向视网膜神经元分化是治疗神经退行性疾病的有效疗法. 然而 …

Two of the most common neurodegenerative disorders–Alzheimer's and Parkinson's
diseases–are characterized by synaptic dysfunction and degeneration that culminate in …

The discovery of four factor (4F)-induced reprogramming of somatic cells into induced
pluripotent stem (iPS) cells has revolutionized the fields of cell and regenerative biology. In …