Treatment and prevention of malaria in children
EA Ashley, JR Poespoprodjo - The Lancet Child & Adolescent …, 2020 - thelancet.com
Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …
Development of an evidence evaluation and synthesis system for drug-drug interactions, and its application to a systematic review of HIV and malaria co-infection
K Seden, S Gibbons, C Marzolini, JM Schapiro… - PLoS …, 2017 - journals.plos.org
Background In all settings, there are challenges associated with safely treating patients with
multimorbidity and polypharmacy. The need to characterise, understand and limit harms …
multimorbidity and polypharmacy. The need to characterise, understand and limit harms …
CYP2B6* 6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response …
BA Maganda, OMS Minzi, E Ngaimisi… - The …, 2016 - nature.com
We investigated the influence of efavirenz (EFV)-or nevirapine (NVP)-based antiretroviral
therapy (ART) on lumefantrine plasma exposure in HIV-malaria-coinfected patients and …
therapy (ART) on lumefantrine plasma exposure in HIV-malaria-coinfected patients and …
The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV …
BA Maganda, E Ngaimisi, AAR Kamuhabwa, E Aklillu… - Malaria journal, 2015 - Springer
Background HIV-malaria co-infected patients in most parts of sub-Saharan Africa are treated
with both artemether-lumefantrine (AL) and efavirenz (EFV) or nevirapine (NVP)-based …
with both artemether-lumefantrine (AL) and efavirenz (EFV) or nevirapine (NVP)-based …
The interaction between artemether-lumefantrine and lopinavir/ritonavir-based antiretroviral therapy in HIV-1 infected patients
Background Artemether-lumefantrine is currently the most widely recommended treatment of
uncomplicated malaria. Lopinavir–based antiretroviral therapy is the commonly …
uncomplicated malaria. Lopinavir–based antiretroviral therapy is the commonly …
In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology
LH Du Plessis, K Govender, P Denti… - European Journal of …, 2015 - Elsevier
The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is
typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic …
typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic …
Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether‐lumefantrine for uncomplicated malaria
P Chotsiri, L Denoeud‐Ndam, E Baudin… - Clinical …, 2019 - Wiley Online Library
Severe acute malnutrition (SAM) has been reported to be associated with increased malaria
morbidity in Sub‐Saharan African children and may affect the pharmacology of antimalarial …
morbidity in Sub‐Saharan African children and may affect the pharmacology of antimalarial …
An individual participant data population pharmacokinetic meta-analysis of drug-drug interactions between lumefantrine and commonly used antiretroviral treatment
Treating malaria in HIV-coinfected individuals should consider potential drug-drug
interactions. Artemether-lumefantrine is the most widely recommended treatment for …
interactions. Artemether-lumefantrine is the most widely recommended treatment for …
Antiretroviral choice for HIV impacts antimalarial exposure and treatment outcomes in Ugandan children
Background. The optimal treatment of malaria in human immunodeficiency virus (HIV)–
infected children requires consideration of critical drug–drug interactions in coinfected …
infected children requires consideration of critical drug–drug interactions in coinfected …