Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade

F Chiti, CM Dobson - Annual review of biochemistry, 2017 - annualreviews.org
Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …

α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis

S Mehra, S Sahay, SK Maji - Biochimica et Biophysica Acta (BBA)-Proteins …, 2019 - Elsevier
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

M Jucker, LC Walker - Nature neuroscience, 2018 - nature.com
Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …

Recent insights into the roles of circular RNAs in human brain development and neurologic diseases

S Najafi, SMA Zarch, J Majidpoor, S Pordel… - International Journal of …, 2023 - Elsevier
Circular RNAs (circRNAs) are a novel class of non-coding RNAs. They are single-stranded
RNA transcripts characterized with a closed loop structure making them resistant to …

The unfolded protein response in neurodegenerative disorders–therapeutic modulation of the PERK pathway

D Hughes, GR Mallucci - The FEBS journal, 2019 - Wiley Online Library
The unfolded protein response (UPR) is a highly conserved protein quality control
mechanism, activated in response to Endoplasmic Reticulum (ER) stress. Signalling is …

[HTML][HTML] Epidemiological characteristics of human prion diseases

C Chen, XP Dong - Infectious diseases of poverty, 2016 - Springer
Human prion diseases are a group of transmissible, progressive, and invariably fatal
neurodegenerative disorders, which include Kuru, Creutzfeldt-Jakob disease (CJD) …

[HTML][HTML] Structural and functional insights into α-synuclein fibril polymorphism

S Mehra, L Gadhe, R Bera, AS Sawner, SK Maji - Biomolecules, 2021 - mdpi.com
Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …

Bushmeat and emerging infectious diseases: lessons from Africa

LA Kurpiers, B Schulte-Herbrüggen, I Ejotre… - Problematic wildlife: A …, 2016 - Springer
Zoonotic diseases are the main contributor to emerging infectious diseases (EIDs) and
present a major threat to global public health. Bushmeat is an important source of protein …

Human prion diseases: surgical lessons learned from iatrogenic prion transmission

DJ Bonda, S Manjila, P Mehndiratta, F Khan… - Neurosurgical …, 2016 - thejns.org
The human prion diseases, or transmissible spongiform encephalopathies, have captivated
our imaginations since their discovery in the Fore linguistic group in Papua New Guinea in …

[HTML][HTML] Neurotheranostics as personalized medicines

BD Kevadiya, BM Ottemann, MB Thomas… - Advanced Drug Delivery …, 2019 - Elsevier
The discipline of neurotheranostics was forged to improve diagnostic and therapeutic
clinical outcomes for neurological disorders. Research was facilitated, in largest measure …