The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through …

Gene expression during development and differentiation is regulated in a cell-and stage-
specific manner by complex networks of intergenic and intragenic cis-regulatory elements …

Clonal hematopoiesis (CH) is defined as a single hematopoietic stem/progenitor cell
(HSPC) gaining selective advantage over a broader range of HSPCs. When linked to …

The functionality and longevity of hematopoietic tissue is ensured by a tightly controlled
balance between self-renewal, quiescence, and differentiation of hematopoietic stem cells …

Inflammation is a common defensive response that is activated after different harmful stimuli.
This chronic, or pathological, inflammation is also one of the causes of neoplastic …

Transcription factors (TFs) act within wider regulatory networks to control cell identity and
fate. Numerous TFs, including Scl (Tal1) and PU. 1 (Spi1), are known regulators of …

Cellular differentiation requires precisely regulated tissue‐specific and developmental stage‐
specific gene expression patterns. Numerous studies have highlighted the predictive power …

Clonal hematopoiesis (CH) increases risk for the development of hematological malignancy
and cardiovascular disease. IL1β is elevated in patients with CH and its inhibition mitigates …

Enhancers are the primary determinants of cell identity, and specific promoter/enhancer
combinations of Endoglin (ENG) have been shown to target blood and endothelium in the …

Clonal hematopoiesis (CH) increases the risk for the development of hematological
malignancy and cardiovascular disease. IL1β is elevated in patients with CH and its …