The role of peripheral physiology in the experience of emotion has been debated since the
19th century following the seminal proposal by William James that somatic responses to …

African Americans disproportionately suffer more severe and debilitating morbidity from
chronic pain than do non-Hispanic Whites. These differences may arise from differential …

Accumulating evidence suggests that epigenetic alterations lie behind the induction and
maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by …

Chronic pain is a major public health issue with an incidence of 20–25% worldwide that can
take different forms like neuropathic, cancer-related or inflammatory pain. Chronic pain often …

Chronic pain reduces life quality and is an important clinical problem associated with
emotional and cognitive dysfunction. Epigenetic regulation of DNA methylation is involved in …

Objective: Pain is one of the most common reasons for an individual to consult their primary
care physician, with most chronic pain being treated in the primary care setting. However …

Visceral pain is generally poorly localized and characterized by hypersensitivity to a
stimulus such as organ distension. In concert with chronic visceral pain, there is a high …

Neuropathic pain (NP) is an intolerable pain syndrome that arises from continuous
inflammation and excitability after nerve injury. Only a few NP therapeutics are currently …

More than 20% of adults worldwide experience different types of chronic pain, which are
frequently associated with several comorbidities and a decrease in quality of life. Several …

Alteration in gene expression along the pain signaling pathway is a key mechanism
contributing to the genesis of neuropathic pain. Accumulating studies have shown that …