Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Focal adhesions are large protein complexes organized at the basal surface of cells, which
physically connect the extracellular matrix to the cytoskeleton and have long been …

Defects in nuclear morphology often correlate with the onset of disease, including cancer,
progeria, cardiomyopathy, and muscular dystrophy. However, the mechanism by which a …

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces
regulate a large array of physiological processes, and dysregulation of mechanical …

A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

Dysfunctional endothelial cells are an essential contributor to the progression of diverse
chronic cardiovascular, renal, and metabolic diseases. It manifests in impairment of nitric …

To provide a systematic analysis of genes that regulate epithelial cell migration, we
performed a high throughput wound healing screen with MCF-10A breast epithelial cells …

Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that
lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse …