▪ Abstract Human leukemias are typified by acquired recurring chromosomal translocations.
Cloning of these translocation breakpoints has provided important insights into …

Core-binding factors (CBFs) are a class of haematopoietic transcription factors that are
crucial for the regulation of haematopoietic ontogeny, and are frequent targets of mutation …

A common chromosomal translocation in acute myeloid leukemia (AML) involves the AML1
(acute myeloid leukemia 1, also called RUNX1, core binding factor protein (CBFα), and …

The acute myeloid leukemia (AML)-associated translocation products AML1-ETO, PML-
retinoic acid receptor alpha (RARα), and PLZF-RARα encode aberrant transcription factors …

Vitamin D 3 upregulated protein 1 (VDUP1) is a 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D
3) upregulated protein, and it is induced by various stresses. In human tumor tissues …

The past decade has yielded immense progress in the understanding of the pathogenesis of
acute leukemia. The cloning of consistent chromosomal breakpoints associated with …

Acute promyelocytic leukemia (APL) has been recognized as a distinct clinical entity for over
40 years. Although relatively rare among hematopoietic malignancies (approximately 10 …

The promyelocytic leukemia zinc finger (PLZF) protein, also known as Zbtb16 or Zfp145, was
first identified in a patient with acute promyelocytic leukemia, where a reciprocal …

Histone deacetylases (HDACs) have recently emerged as an important target for therapeutic
intervention in cancer and potentially other human diseases. By modulating the acetylation …

Abstract The translocation t (8; 21)(q22; q22) in acute myeloid leukemia (AML) results in the
expression of the fusion protein RUNX1/MTG8, which in turn recruits histone deacetylases …