Folate receptor α (FRα) came into focus as an anticancer target many decades after the
successful development of drugs targeting intracellular folate metabolism, such as …

Conventional chemotherapy lacking target selectivity often leads to severe side effects,
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …

Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to
differentiate into multiple cell types. Several studies have shown that exosomes secreted by …

Short interfering RNAs (siRNAs), as small non-coding RNA fragments, are one of the widely
studied RNAi inducers for gene modulations. The reasonably designed siRNA probes …

Cancer is one of the primary causes of death worldwide, and its morbidity and mortality rates
are increasing rapidly. However, standard treatment modalities (surgery, radiotherapy …

Cancer is the second largest cause of death worldwide with the number of new cancer
cases predicted to grow significantly in the next decades. Biotechnology and medicine can …

Abstract Purpose: MORAb-202, an antibody–drug conjugate containing farletuzumab and
eribulin with a cathepsin-B cleavable linker, targets folate receptor α (FRα)–expressing …

Purpose OTL38 is a folate-indole-cyanine green-like conjugate to folate receptor alpha
(FRa). The objectives of this prospective trial were to assess the safety and efficacy …

Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover
occurring in cancer cell proliferation. Though the role of folate as a causative versus …

There remains a vital necessity for new therapeutic approaches to combat metastatic
cancers, which cause globally over 8 million deaths per year. Mesenchymal stem cells …