The folding of many newly synthesized proteins in the cell depends on a set of conserved proteins known as molecular chaperones. These prevent the formation of misfolded protein …
X Luo, HB Gong, HY Gao, YP Wu, WY Sun… - Cell Death & …, 2021 - nature.com
During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary …
ET Wang, NAL Cody, S Jog, M Biancolella, TT Wang… - Cell, 2012 - cell.com
The muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG …
Immunoglobulins are the major secretory products of the adaptive immune system. Each is characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
AR van Vliet, T Verfaillie, P Agostinis - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
In all eukaryotic cells, the endoplasmic reticulum (ER) and the mitochondria establish a tight interplay, which is structurally and functionally modulated through a proteinaceous tether …
J Verghese, J Abrams, Y Wang… - … and molecular biology …, 2012 - Am Soc Microbiol
The eukaryotic heat shock response is an ancient and highly conserved transcriptional program that results in the immediate synthesis of a battery of cytoprotective genes in the …
AL Fink - Physiological reviews, 1999 - journals.physiology.org
The folding of most newly synthesized proteins in the cell requires the interaction of a variety of protein cofactors known as molecular chaperones. These molecules recognize and bind …
M Michalak, EF CORBETT, N MESAELI… - Biochemical …, 1999 - portlandpress.com
The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of membrane-associated and secreted proteins. The membrane is also an important site of …
FF Chehab, K Mounzih, R Lu, ME Lim - Science, 1997 - science.org
Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the …