Chronic kidney disease (CKD) results in systemic inflammation and oxidative stress which
play a central role in CKD progression and its adverse consequences. Although many of the …

The first reports connecting uremic inflammation with a wasted and atherogenic phenotype
and poor outcome initiated in the late 1990s. Since then, about 3500 publications appear on …

Background The microbial metabolite Trimethylamine-N-oxide (TMAO) has been linked to
adverse cardiovascular outcome and mortality in the general population. Objective To …

Inflammation is a major mediator of CKD progression and is partly driven by altered gut
microbiome and intestinal barrier disruption, events which are caused by: urea influx in the …

Rationale & Objective Chronic kidney disease (CKD)-associated pruritus, generalized
itching related to CKD, affects many aspects of hemodialysis patients' lives. However …

The bacteria community living in the gut maintains a symbiotic relationship with the host and
its unbalance has been associated with progression of a wide range of intestinal and extra …

Aim: To investigate whether gut bacteria translocation occurs in end‐stage renal disease
patients and contributes to microinflammation in end‐stage renal disease (ESRD). Methods …

During chronic kidney disease (CKD), typical alterations in the gut microbiota are observed.
The kidney no longer plays the role of the main excretory organ as this function is performed …

Abstract Background/Aims Bacterial translocation (BT) promotes microinflammation in
predialysis patients with end-stage renal disease (ESRD). However, the change in BT has …

Blood levels of urea rise with progressive decline in kidney function. Older studies
examining acute urea infusion suggested that urea was well-tolerated at levels 8–10× above …