Intron retention (IR) is a form of alternative splicing that has long been neglected in
mammalian systems although it has been studied for decades in non-mammalian species …

Alternative splicing plays a key role in the HIV-1 life cycle and is essential to maintain an
equilibrium of mRNAs that encode viral proteins and polyprotein-isoforms. In particular …

To replicate and disseminate, viruses need to manipulate and modify the cellular machinery
for their own benefit. We are interested in translation, which is one of the key steps of gene …

Intron retention (IR), where one or more introns remain in the RNA after splicing, was long
thought to be rare in mammalian cells, albeit common in plants and some viruses. Largely …

Y-box proteins are single-strand DNA-and RNA-binding proteins distinguished by a
conserved cold shock domain (CSD) and a variable C-terminal domain organized into …

The Nxf1 protein is a major nuclear export receptor for the transport of mRNA, and it also is
essential for export of retroviral mRNAs with retained introns. In the latter case, it binds to …

During HIV infection, intron-containing viral mRNAs are exported from the cell nucleus to the
cytoplasm to complete the replication cycle. Cellular restrictions on the export of …

The complex between the Rev protein of HIV-1 and the Rev Recognition Element (RRE)
within the virus RNA promotes nuclear export of unspliced or incompletely spliced viral …

Transcription complexes that assemble at the HIV-1 promoter efficiently initiate transcription
but generate paused RNA polymerase II downstream from the start site. The virally encoded …

The Rev protein of HIV-1 binds to the Rev Recognition Element (RRE) in the virus RNA to
promote nuclear export of unspliced and partially spliced transcripts, an essential step in the …