Psychiatric disorders are often distinguished from neurological disorders in that the former
do not have characteristic lesions or findings from cerebrospinal fluid …

Trace elements play a crucial role in many biochemical processes, mainly as components of
vitamins and enzymes. Although small amounts of metal ions have protective properties …

Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional
Amerindian medicine recently associated with cognitive gains, antidepressant effects, and …

Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …

An organoid is a miniaturized and simplified in vitro model with a similar structure and
function to a real organ. In recent years, the use of organoids has increased explosively in …

Many metals have biological functions and play important roles in human health. Copper
(Cu) is an essential metal that supports normal cellular physiology. Significant research …

Background Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide
range of debilitating symptoms. Several aspects of its multifactorial complexity are still …

The limited access to functional human brain tissue has led to the development of stem cell-
based alternative models. The differentiation of human pluripotent stem cells into cerebral …

Purpose: Since their first generation in 2013, the use of cerebral organoids has spread
exponentially. Today, the amount of generated data is becoming challenging to analyze …

Background Organoid cultivation in suspension culture requires agitation at low shear stress
to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for …