Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Therapeutic oxygen delivery by perfluorocarbon-based colloids
MP Krafft, JG Riess - Advances in colloid and interface science, 2021 - Elsevier
After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …
A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
Application of a sub–0.1-mm3 implantable mote for in vivo real-time wireless temperature sensing
There has been increasing interest in wireless, miniaturized implantable medical devices for
in vivo and in situ physiological monitoring. Here, we present such an implant that uses a …
in vivo and in situ physiological monitoring. Here, we present such an implant that uses a …
Acoustically targeted chemogenetics for the non-invasive control of neural circuits
JO Szablowski, A Lee-Gosselin, B Lue… - Nature biomedical …, 2018 - nature.com
Neurological and psychiatric disorders are often characterized by dysfunctional neural
circuits in specific regions of the brain. Existing treatment strategies, including the use of …
circuits in specific regions of the brain. Existing treatment strategies, including the use of …
[HTML][HTML] Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the
passage of drugs into brain. Central nervous system tumors can impair the BBB by changing …
passage of drugs into brain. Central nervous system tumors can impair the BBB by changing …
[HTML][HTML] Using a novel rapid alternating steering angles pulse sequence to evaluate the impact of theranostic ultrasound-mediated ultra-short pulse length on blood …
Background: Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is a
noninvasive, safe and reversible technique for targeted drug delivery to the brain. Most …
noninvasive, safe and reversible technique for targeted drug delivery to the brain. Most …
In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound:[18F] DPA-714 PET study
S Sinharay, TW Tu, ZI Kovacs… - Journal of …, 2019 - Springer
Background Magnetic resonance imaging (MRI)-guided pulsed focused ultrasound
combined with the infusion of microbubbles (pFUS+ MB) induces transient blood-brain …
combined with the infusion of microbubbles (pFUS+ MB) induces transient blood-brain …
Improved source localization in passive acoustic mapping using delay-multiply-and-sum beamforming with virtually augmented aperture
CC Shen, YA Chen, HY Ku - Ultrasonics, 2023 - Elsevier
High-intensity focused ultrasound (HIFU) is a promising non-invasive treatment method
whose applications include tissue ablation, hemostasis, thrombolysis and blood–brain …
whose applications include tissue ablation, hemostasis, thrombolysis and blood–brain …
Focused ultrasound for noninvasive, focal pharmacologic neurointervention
A long-standing goal of translational neuroscience is the ability to noninvasively deliver
therapeutic agents to specific brain regions with high spatiotemporal resolution. Focused …
therapeutic agents to specific brain regions with high spatiotemporal resolution. Focused …