Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Human early development sets the stage for embryonic and adult life but remains difficult to
investigate. A solution came from the ability of stem cells to organize into structures …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Human pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative
medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional …

Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of
the mammalian placenta, however, the contribution of ERVs to placental development and …

In contrast to rodents, the mechanisms underlying human trophectoderm and early placenta
specification are understudied due to ethical barriers and the scarcity of embryos. Recent …

X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of
gene expression, wherein the long non-coding RNA XIST spreads across the X …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing
hundreds of hiPSCs derived from different individuals, we show the proportions of these …

Embryonic development is a highly intricate and complex process. Different regulatory
mechanisms cooperatively dictate the fate of cells as they progress from pluripotent stem …