Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …

Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

The intestinal epithelium constitutes an indispensable single-layered barrier to protect the
body from invading pathogens, antigens or toxins. At the same time, beneficial nutrients and …

Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

The emergence of novel immunomodulatory cancer therapies over the last decade, above
all immune checkpoint blockade, has significantly advanced tumor treatment. For colorectal …

Colorectal cancer (CRC) develops by genetic and epigenetic alterations. However, the
molecular mechanisms underlying metastatic dissemination remain unclear and could …

Pre-clinical and clinical data produce mounting evidence that the microbiota is strongly
associated with colorectal carcinogenesis. Dysbiosis may change the course of …

Colorectal cancer (CRC) is the second leading cause of death in cancer patients in the USA,
whereas the major cause of CRC deaths is hepatic metastases. The liver is the most …

The early onset of colorectal cancer (CRC) in individuals younger than 50 years is an
emerging phenomenon, and obesity is a strong risk factor. Inflammatory mechanisms are …

Cancer is the primary cause of death in economically developed countries and the second
leading cause in developing countries. Colorectal cancer (CRC) is the third most common …